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Integrative Multi-Omics in Biomedical Research

Genomics technologies revolutionised biomedicine research, but the genome alone is not sufficient to capture biological complexity. Postgenomic methods, typically based on mass spectrometry, comprise the analysis of metabolites, lipids, and proteins and are an essential complement to genomics and tr...

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Salvato in:
Natura: Online
Lingua:inglese
Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute 2022
Soggetti:
target identification
target validation
label-free method for drugs
anti-angiogenesis
mechanism of action
receptor tyrosine kinases
curcumin
natural products
lipid
lipidomics
cardiac metaplasia
Barrett’s esophagus
esophageal adenocarcinoma
microbiota
DNA sensing
IFI16
cGAS
innate immunity
protein interactions
virus–host interactions
post-translational modifications
mass spectrometry
proteomics
transcriptomics
multi-omics
multi-omics analysis
study design
bioinformatics
machine learning
analysis flow
metabolomics
planned myocardial infarction (PMI)
myocardial infarction (MI)
exercise
heart
cheminformatics
batch variations
eicosanoids
fetal calf serum
peroxisomes
host-pathogen interactions
secretome
macrophages
acute myeloid leukemia
HL-60 cell line
ATRA
induced differentiation
transcriptome
proteome
transcription factors
key molecules
regulatory pathway modelling
SRM
endometriosis
inflammation
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Accesso online:ONIX_20220111_9783036525822_918
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Riassunto:Genomics technologies revolutionised biomedicine research, but the genome alone is not sufficient to capture biological complexity. Postgenomic methods, typically based on mass spectrometry, comprise the analysis of metabolites, lipids, and proteins and are an essential complement to genomics and transcriptomics. Multidimensional omics is becoming established to provide accurate and comprehensive state descriptions. This book covers the latest methodological developments for, and applications of integrative multi-omics in biomedical research.

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