Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other?
Somatic stem cells reside in definite compartments, known as “niches”, within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic st...
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| Formáid: | Online |
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Frontiers Media SA
2021
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| Ábhair: | |
| Rochtain ar líne: | 18895 |
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Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| _version_ | 1865100010933190656 |
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| author | Maria Concetta Geloso Wanda Lattanzi |
| author_browse | Maria Concetta Geloso Wanda Lattanzi |
| author_facet | Maria Concetta Geloso Wanda Lattanzi |
| author_sort | Maria Concetta Geloso |
| collection | Directory of Open Access Books |
| description | Somatic stem cells reside in definite compartments, known as “niches”, within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organ, including brain and heart. The adult bone marrow, in particular, houses a complex multifunctional niche comprising hemopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), that intensely interact. HSCs represent the common precursors of all mature blood cells. MSCs are instead able to differentiate along multiple mesodermal lineages and are believed to represent the key somatic stem cell within the skeletogenic niche, being conceptually able to produce any tissue included within a mature skeletal segment (bone, cartilage, blood vessels, adipose tissue, and supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal lineages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors’ lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreaking research achievements in the field of regenerative medicine, along with the pressing need for effective innovative tools for the treatment of neurodegeneration and neurologic disorders, have been forcing experimental clinical applications, which, despite their scientific weakness, have recently stimulated the public opinion. Based on this contemporary background, this Research Topic wish to provide an in-depth revision of the state of the art on relevant scientific milestones addressing the differences and possible interconnections and overlaps, between the osteogenic and the neurogenic niches. Dissertations on both basic research and clinical aspects, along with ethical and regulatory issues on the use of somatic stem cells for in vivo transplantation, have been covered. |
| format | Online |
| id | doab-20.500.12854ir-44313 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-443132024-04-05T12:35:18Z Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other? Maria Concetta Geloso Wanda Lattanzi RC321-571 Q1-390 Neuropeptide Y Stem Cell Niche Mesenchymal Stromal Cells Neural Stem Cells Regenerative Medicine Wnt/beta-catenin signaling Bone Marrow Neural Crest RUNX2 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Somatic stem cells reside in definite compartments, known as “niches”, within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organ, including brain and heart. The adult bone marrow, in particular, houses a complex multifunctional niche comprising hemopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), that intensely interact. HSCs represent the common precursors of all mature blood cells. MSCs are instead able to differentiate along multiple mesodermal lineages and are believed to represent the key somatic stem cell within the skeletogenic niche, being conceptually able to produce any tissue included within a mature skeletal segment (bone, cartilage, blood vessels, adipose tissue, and supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal lineages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors’ lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreaking research achievements in the field of regenerative medicine, along with the pressing need for effective innovative tools for the treatment of neurodegeneration and neurologic disorders, have been forcing experimental clinical applications, which, despite their scientific weakness, have recently stimulated the public opinion. Based on this contemporary background, this Research Topic wish to provide an in-depth revision of the state of the art on relevant scientific milestones addressing the differences and possible interconnections and overlaps, between the osteogenic and the neurogenic niches. Dissertations on both basic research and clinical aspects, along with ethical and regulatory issues on the use of somatic stem cells for in vivo transplantation, have been covered. 2021-02-11T10:48:19Z 2021-02-11T10:48:19Z 2016-04-07 11:22:02 2016 book 18895 16648714 9782889197774 https://directory.doabooks.org/handle/20.500.12854/44313 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Crosstalk_between_the_Osteogenic_and_Neurogenic_Stem_Cell_Niches_How_Far_are_They_from_Each_Other_/819#nogo http://journal.frontiersin.org/researchtopic/2763/crosstalk-between-the-osteogenic-and-neurogenic-stem-cell-niches-how-far-are-they-from-each-other Frontiers Media SA 10.3389/978-2-88919-777-4 10.3389/978-2-88919-777-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197774 102 open access |
| spellingShingle | RC321-571 Q1-390 Neuropeptide Y Stem Cell Niche Mesenchymal Stromal Cells Neural Stem Cells Regenerative Medicine Wnt/beta-catenin signaling Bone Marrow Neural Crest RUNX2 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Maria Concetta Geloso Wanda Lattanzi Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other? |
| title | Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other? |
| title_full | Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other? |
| title_fullStr | Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other? |
| title_full_unstemmed | Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other? |
| title_short | Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other? |
| title_sort | crosstalk between the osteogenic and neurogenic stem cell niches how far are they from each other |
| topic | RC321-571 Q1-390 Neuropeptide Y Stem Cell Niche Mesenchymal Stromal Cells Neural Stem Cells Regenerative Medicine Wnt/beta-catenin signaling Bone Marrow Neural Crest RUNX2 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Neuropeptide Y Stem Cell Niche Mesenchymal Stromal Cells Neural Stem Cells Regenerative Medicine Wnt/beta-catenin signaling Bone Marrow Neural Crest RUNX2 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18895 |
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